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On the other hand, a recent network meta-analysis [32] indirectly compared CV effects among different GLP-1RA in patients with T2DM and did not find any significant difference between GLP1RA in reducing death from any cause, MI and stroke events

While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown

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In June 2025, MBX Biosciences In announced it received preliminary feedback from the FDA on its planned Type B pre-IND meeting, supporting the advancement of its EL-22 program in combination with GLP-1 receptor agonists toward a Phase 2 clinical trial