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Therefore, HO-1 activity inhibits M1 markers and pro-inflammatory cytokines, aiding the transition from M1 to M2 and Mreg, attenuating immune responses, which may paradoxically benefit the survival of H

The interest stems from theoretical anti-inflammatory and vascular effects

Cell death was analysed using Annexin-V AF488 (Thermo Fisher Scientific, A13201) and Sytox blue (Thermo Fisher Scientific, S34857)

Superposing the structures based on the S1S3 helices of a single protomer, neither of the Ator13 molecules can fit in the closed-state structure