semaglutide vs farxiga Tirzepatide 💉⚖️ Both are powerful medications for diabetes and weight loss, but tirzepatide's dual GIP + GLP-1 action may lead to even greater weight loss and glucose control. Semaglutide offers Type 2 diabetes: New Ozempic

NNMT and Cancer Elevated NNMT expression has been observed in several forms of cancer, including gastric, pancreatic, renal cell carcinoma, and bladder cancers

GLP-1 agonists work primarily through gut-brain signaling and slowed gastric emptying

Effects on congestive heart failure-associated myopathy may be due to caspase inhibition and decreased TNF-alpha levels (14)

There was also a slight increase in the number of foot and toe amputations during the CANVAS trial than is usual so further studies are needed to assess if this is a problem and who is more at risk

for example, when comparing former elite weightlifters to shooters after participating a mean of 26 years in their respective sport 15,16

Intravenous administration might be better in some cases