For sustained results, semaglutide likely needs to be continued long-term, and healthy diet and exercise remain critical to maintain weight loss
Lingvay I, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, et al
Byetta (exenatide): Discontinued Drug class: GLP-1 Agonists What was Byetta
* ZollingerEllison syndrome: Start 60 mg once daily
However, a pharmacovigilance study using the WHO's global adverse drug reaction database found disproportionate reporting of eating disorder adverse events with all three major GLP-1 medications ( Nishida et al., Clinical Nutrition, 2025 )
Although GLP-1RAs improve mobility and reduce body weight, some patients decrease physical activity during treatment due to fatigue or altered energy perception