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A favorable effect was noticed on the level of IL-6 and IGF-1, but this effect did not reach a significant level

Both genetic factors (e.g., VDR polymorphisms) and environment (e.g., low UVB exposure, low dietary vitamin D intake) may contribute to the low vitamin D status observed in these autoimmune diseases (110)

Conlon TM et al

SC: semanas corregidas

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114 The density of AMPA, NMDA and P2X receptors as well as the density of plasmalemmal glutamate transporter currents demonstrates bell-shaped age dependency, with maximal densities observed in adult animals, whereas ageing is accompanied by a 2-3 fold decrease of density of respective ion currents