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Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes

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Proteomics 15 , 837849 (2018)

doi: 10.1016/j.physbeh.2011.12.001

Side effects peak during weeks 6-8 and typically resolve by week 12, with 88.8% of participants completing the full 48-week trial successfully

The monthly $149 membership fee is required for all patients after the first month and is billed separately from medication