And this approach should only be considered by people already well-established on their GLP-1 dose with stable side effects and confident protein targets being met on normal days
Starting at 2.5 mg once a week, most individuals stay on that initial dose for at least four weeks before considering an increase
In the landmark STEP 1 trial published in the New England Journal of Medicine , participants lost an average of 14.9% of body weight over 68 weeks on semaglutide 2.4mg, compared to 2.4% on placebo
This start low and go slow approach gives your body time to get used to the medication
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However, it may be risky in combination with certain medicines, such as the following