1298A (leading to a Glu at amino acid 429) is the most common while 1298C (leading to an Ala substitution at amino acid 429) is less common
Individual risk depends on baseline bone health, genetics, and lifestyle factors
Blood sugar effects Avoid stacking berberine or other glucose-lowering supplements with diabetes medication unless your clinician approves it

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& Blumberg, B
Its action on GIP receptors enhances insulin secretion and glucose reuptake, which lowers blood sugar levels