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However, despite their significant quality of life improvements, they can be accompanied by significant gastrointestinal side effects, including nausea, vomiting, abdominal pain, diarrhea, fatigue, and weight loss 16
Who should consider microdosing
In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)
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However, semaglutide can still be an effective weight loss medication for adults, especially when combined with a healthy diet and exercise
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