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First, exclude other causes of musculoskeletal symptoms, including inflammatory arthritis, infection, trauma, or medication interactions

The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

There isnt enough reliable information available to determine its safety during pregnancy and breastfeeding

Low SAM, excessive methylation demand, impaired creatine synthesis, reduced glutathione availability and oxidative stress may place additional strain on mitochondria, potentially contributing to fatigue, variable cognitive stamina, sensory sensitivity, poor stress tolerance and slow recovery from illness

Accessed 04 June 2024

Chirumbolo S, Valdenassi L, Tirelli U, Ricevuti G, Pandolfi S, Vaiano F, Galoforo A, Loprete F, Simonetti V, Chierchia M, Bellardi D, Richelmi T, Franzini M (2023b) The oxygen-ozone adjunct medical treatment according to the protocols from the Italian Scientific Society of Oxygen-Ozone Therapy: how ozone applications in the blood can influence clinical therapy success via the modulation of cell biology and immunity