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Frequencies range from weekly to monthly, depending on your goals and baseline levels

This happens due to a lack of an intrinsic factor, a protein necessary for B12 absorption in the stomach

(Thats why vitamin B12 is often treated with B12 injections fewer barriers to absorption!) A different small study on people who underwent gastric bypass surgery found that higher doses of oral B12 supplements (1,000 to 2,000 mcg) are about as effective as injections

TB-500 has similarly demonstrated benefits in tendon repair through its effects on cellular migration and angiogenesis, with studies showing improved healing quality and reduced scar tissue formation

Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history

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