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The aim is not just short-term weight reduction, but long-term health improvement and reduced risk of obesity-related conditions
Two recent studies in the JCI provide insight into the neurons responsible for this effect
A prespecified analysis found the kidney effect to be directionally consistent regardless of baseline SGLT2i use, with no significant treatment-by-subgroup interaction, although only a small minority of participants were taking an SGLT2i at entry, so the combination subgroup was underpowered and does not by itself establish additive benefit
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