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While short-term efficacy is well-documented, concerns remain about the long-term impact of prolonged GLP-1 receptor activation, particularly in non-diabetic populations
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The absence of exendin-4 effect in obese rats maintains AMPK activity at a level of activation similar to the lean animals after the administration of exendin-4 [83] (Figure 5)
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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