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14 In contrast, Weschawalit et al 3 reported a statistically significant effect of glutathione as a skin-lightening agent, but this was limited to a group of participants aged older than 40 years who received GSH, a reduced form of glutathione, on the sun-exposed area of the right forearm

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Thus, in the well-fed state, insulin enhances the carbon flux through the pentose phosphate pathway, increasing NADPH production Note: insulin also promotes fatty acid synthesis, which depends on a continuous supply of NADPH

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10.1016/j.lfs.2018.12.029 5