joint pain glp-1 medications may help improve inflammation, but not because they are “anti-inflammatory drugs.” They improve many of the metabolic drivers of chronic inflammation: • Decreasing visceral fat • Improving insulin resistance GLP-1 Chronic Pain Relief: Weight

It causes the blood vessels to relax and regulates smooth muscle activity, epithelial cell secretion, and blood flow in the gastrointestinal tract

Dose escalation identified dose-limiting toxicitiesprimarily thrombocytopenia and neutropeniawith the maximum tolerated dose established at 675 mg/m weekly

Patients with diabetes should be advised that while allulose does not significantly raise blood glucose, it should not replace established diabetes management strategies, including prescribed medications, dietary modifications, and regular monitoring

doi: 10.1111/and.13039 35 HibiHOhoriTYamadaY

In preclinical studies, the drug has shown strong anti-tumor activity and survival advantage in AML, DLBCL, cALL, and Burkitt lymphoma tumor models

Faxn UL et al