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They demonstrated by linear regression analysis that PTH was independently associated with the degree of eryptosis evaluated by flow cytometry and hypothesized that PTH could represent a new potential pathogenic mechanism linking hyperparathyroidism with renal anemia in HD patients [264]
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In particular, the initial burst of superoxide that cannot be eliminated efficiently due to the inactivity of SOD1 is promptly buffered by the induction of GSH synthesis resulting in protection against oxidative stress and cell death