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Initially, we anticipated that GEP44 would reduce serum glucose levels via binding to GLP-1R

The article says injectable tirzepatide has extensive clinical trial data while sublingual data is more limited, with early studies suggesting a comparable or slightly lower magnitude of effect

These observations provide a novel theoretical foundation for the treatment of OP via targeting the GM5-HT axis, indicating that suppression of gut-derived 5-HT biosynthesis may serve as a promising anabolic approach for bone health

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