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Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation

Embla Clinic study (ECO 2024) EASO Conference Abstract Personalized dosing and tapering of semaglutide for weight maintenance (Is coming off semaglutide slowly the key to preventing weight regain

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Either people really have to accept this as a treatment for life,, or we in science need to think really, really hard, how to support people when they stop the drug. While the study did not show causality, Jebb speculated that the difference in how fast people put weight back on could be due to the fact that diets are hard and people have to practise restraint to lose weight, whereas if you are taking a drug that knocks your hunger out completely, you dont have to make that effort

These include: Nausea (very common), typically most pronounced in the first few weeks Vomiting and diarrhoea (common), which can contribute to dehydration Constipation (common), which may require dietary adjustments Abdominal pain and bloating (common), related to delayed gastric emptying Reduced appetite (very common), which whilst therapeutically beneficial for weight loss, may lead to inadequate nutrition if extreme These effects usually diminish over time as tolerance develops