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Some patients and clinicians have explored extended dosing intervals due to various factors including medication cost, supply shortages, injection fatigue, or perceived adequate response at lower frequencies
The reconstitution volume also differs: the combo vial uses 2mL of bacteriostatic water rather than 2.5mL, so the unit-to-milligram conversion changes
It also considers subjective factors such as the publics demand for recreation, behavioural patterns and perceptual experiences
But a question begins to form in the back of your mind: 'Is this forever
Phase 2 trials (NEJM, 2023) reported mean resting heart rate increases of approximately 57 bpm at doses of 8 mg and 12 mg weekly
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