The American Diabetes Association (ADA) 2024 Standards of Care support GLP-1 receptor agonists or dual GIP/GLP-1 receptor agonists, including tirzepatide, particularly in patients with: Established atherosclerotic cardiovascular disease or high cardiovascular risk Chronic kidney disease Need for substantial A1c reduction (tirzepatide typically reduces A1c by 1.5-2.5%) Desire to avoid weight gain or achieve weight loss Inadequate glycemic control on metformin or other oral agents Tirzepatide is not approved for type 1 diabetes or diabetic ketoacidosis

Mounjaro (Tirzepatide) Injection 7.5 mg/0.5 mL Prefilled Syringes are a type of medication used to treat type 2 diabetes. They contain the active ingredient tirzepatide, which belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. This medication is delivered as a pre-filled syringe that contains 7.5 mg of tirzepatide in a solution of 0.5 mL. It is given as a subcutaneous injection (under the skin) once a week and works by mimicking the function of a naturally occurring hormone in the body called GLP-1, which helps regulate blood sugar levels. Mounjaro is intended to be used in conjunction with a healthy diet and exercise to help control blood sugar in adults with type 2 diabetes. It may also help in weight management for people with obesity or overweight. As with any medication, it is important to follow the instructions of a healthcare professional and to report any side effects experienced

Neale JH, Yamamoto T (2020) N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: an abundant peptide neurotransmitter-enzyme system with multiple clinical applications
Ill cover how AOD-9604 works (and what it doesnt do), what the human research suggests, why results have been mixed, how it compares to GLP-1/GIP medications, and what legal again actually means in the U.S
The same calculations were applied to the extent of FFM loss
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