These Nox-derived oxidants, especially within retinal and vascular endothelial cells, exacerbate endothelial dysfunction and accelerate BRB breakdown, hallmark microvascular abnormalities leading to microaneurysms, hemorrhages, and neovascularization in DR (66)
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Weeks 33-48: plateauing phase (0.5-1 pound weekly), maintained results
Mike Morey, managing director of the communications firm engaged by the hospital, arranged for them to speak to reporters on the phone while he listened
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