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The severity of HS is classified into three stages using the Hurley staging system

This concept eventually led to drugs like sitagliptin (approved 2006), but those would generally have less potent effects than direct GLP-1 agonists since GLP-1 levels only double or triple on DPP-4 inhibitors (and those drugs rely on some residual pancreatic function and meal stimulation) ( [59] )

It has many important roles

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The HRT and GLP-1 combination guide covers the interaction between these treatments

doi:10.1038/s41370-023-00597-z