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The 20 bp genomic sgRNA target sequence with a 3 bp PAM (underlined) used in this study is shown as follows: sgAlb-E14 (GTTGTGATGTGTTTAGGCTA AGG ), targeting exon 14 of the mouse Albumin ( Alb ) locus
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Likewise, while SGLT2 inhibitors introduce a new class of drugs, they only offer moderate metabolic control, which does not compare to the efficacy of GLP-1 receptor agonist therapy
