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1997;273(1 Pt 1):E185-191
Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer
Kondo, Yoshitaka
Despite promising results showed by pre-clinical studies, anti-VEGF monotherapy such as bevacizumab, sunitinib and aflibercept among others have only provided limited benefits in certain tumor types including advanced-stage renal cell carcinoma, hepatocellular carcinoma and colorectal carcinoma and have not shown efficacy in pancreatic adenocarcinoma, prostate cancer, breast cancer or melanoma [287]
The intent of this change is to drive improved health outcomes, which could have substantial benefits and downstream impacts, but if enacted, the proposed changes will expand coverage criteria, significantly impacting health plans in quick time
FitzGerald, O., Mease, P
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