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If an absolute contraindication applies, the Bridge is not the right path and we discuss alternatives at the visit

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Genetics and biomarker status may help contextualize why some patients report strong early response while others require longer titration windows

Patients are encouraged to follow regulatory progress through official MHRA and NHS England communications, and to identify eligible trials via the NIHR Be Part of Research portal (bepartofresearch.nihr.ac.uk), rather than relying on anecdotal or commercial sources

This same dopamine shift can make food and other reward-driven behaviors feel less satisfying, which some users experience as a temporary muted feeling