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Although the etiology is not well understood, many theories have elaborated on the probable involvement of inflammation

10.1083/jcb.200105057 J

It also happens within the mitochondria , which are the "powerhouses" of your cells that produce energy

However, most synthetic ATs have not yet progressed to clinical trials

Biol Psychiatr 2017;81:402-10

It is postulated that neurotransmitters or neurochemicals released by nerve endings, specifically substance P, can be toxic to melanocytes, causing their destruction in specific areas.92,93 The segmental distribution of vitiligo patches corresponds to the innervation of certain nerves, supporting this hypothesis.92,93 A study analyzing the presence of VZV in segmental vitiligo skin suggests a possible relationship between the 2