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Transdermal-delivery research has repeatedly demonstrated that microneedle-created channels can increase the skin permeation of hydrophilic and larger molecules by many-fold compared with application to intact skin the exact magnitude depends on needle length, density, molecule size, and how soon after treatment the active is applied

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Significant improvement in the symptom score and flow rate was observed with 1 -AR antagonists alone or combination therapy as compared to placebo or finasteride alone, but there was no significant difference observed for combination therapy over 1 -AR antagonists alone

This was supported by the upregulation of adipogenic markers FABP4 and PPAR, with respective increases in mRNA levels of 3.0- and 2.2-fold in comparison to undifferentiated cells [1]