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Some case reports of liver injury and hepatotoxicity have been reported but these have not been observed in controlled studies
Do not assume that a medication should be restarted at the same dose after a treatment gap
Your prescribing doctor may recommend semaglutide to improve glucose control in type 2 diabetes or to support weight management in people with obesity
consideration of dose escalation 6 months : Formal assessment of treatment efficacy according to appropriate criteria: For diabetes (NICE NG28): HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% For weight management: At least 5% weight loss from baseline on maintenance dose (per SmPC and NICE guidance) Annually thereafter : Ongoing monitoring of metabolic parameters, cardiovascular risk factors, and treatment appropriateness Treatment adjustments may be necessary if: Side effects remain intolerable despite supportive measures Weight loss plateaus before reaching target (may warrant dose increase if not at maximum) Inadequate glycaemic control persists (may require additional diabetes medications) Significant weight loss goals are achieved (maintenance strategies and potential dose reduction) Patients should maintain open communication with their healthcare team, reporting both positive developments and concerns
Natural killer cytotoxicity increased two fold in the high-dose group versus placebo at 3 months
Individual responses to dietary changes can vary, especially when combined with medication like Ozempic (semaglutide), Wegovy (semaglutide), and compounded semaglutide
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