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The FDA label for tirzepatide notes that co-administration with a combined oral contraceptive (ethinyl estradiol/norgestimate) resulted in a 55% reduction in ethinyl estradiol Cmax and a 20% reduction in norelgestromin Cmax [3]
10.1001/jama.2023.19574 18 van BloemendaalL.ten KulveJ
Although the dedicated CV outcome trial (CVOT) is still underway, adjudicated 4-P MACE was evaluated in the SURPASS 4 trial, and there was no increase in CV death, myocardial infarction, stroke, or hospitalisation for unstable angina in the tirzepatide group as compared with glargine (hazard ratio: 0.74