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Minor water retention or numbness in extremities at higher doses

(PubMed) Xue YZ, Wang LX, Liu HZ, Qi XW, Wang XH, Ren HZ

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Most GLP-1 agents require gradual dose escalation to minimize gastrointestinal side effects, meaning patients start at lower-than-maintenance titration doses and increase incrementally over 820 weeks depending on the specific medication

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During 1,036,587 person-years of follow-up, cholangiocarcinoma occurred among 92 patients with use of GLP-1-receptor agonists (incidence rate, 26 per 100,000 patient-years) and among 157 patients with use of sulfonylureas (incidence rate, 23 per 100,000 patient-years)