A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]
Moreover, vitamin B12 aids immune regulation, which is crucial for skin disorders involving immune system dysfunction, like eczema, acne, and psoriasis
Anti-Cancer Effect of Pharmacologic Ascorbate and Its Interaction with Supplementary Parenteral Glutathione in Preclinical Cancer Models
This makes it unique among cognitive compounds: it can be taken in forms that reach the brain directly, where it interacts with specific receptor systems that drive the physical growth of neural connections
That said, sometimes lifestyle changes aren't enough to raise glutathione levels, especially if you're dealing with higher oxidative stress, inflammation, or conditions like insulin resistance or liver disease
The limitations of this study include a short study period, lack of follow-up, lack of measurement of serum glutathione levels and the choice of cohort, which consisted of a young and healthy population