A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism
However, if you are ill, high doses of vitamin B12 that you might receive to treat a deficiency may cause some symptoms, such as: What to avoid while taking B12
You can greatly reduce the risk of a bruise by avoiding blood thinning medications and food/drinks prior to injection
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Otherwise, absorption of vitamin b12 interfered