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Animal model research in the published literature has explored dermal and connective tissue applications using topical or localized administration protocols in rodent models

Moreover, NRF2 is required for the survival of hematopoietic stem progenitor cells (HSPCs) and the development of myeloid cells in mice, as NRF2 KO bone marrow had defect in stem cell function and showed reduction of chimerism after transplantation [124]

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Increased membrane binding of erythrocyte catalase in hereditary spherocytosis and in metabolically stressed normal cells

Thus, it attenuated LPS-stimulated eosinophil activation and reduced the generation of IL-4, IL-8, and IL-13 [12]