is tirzepatide still available NO longer in SHORTAGE. What You Need to Know New Tirzepatide Access and Pricing

Taking it more often can increase the risk of side effects

Multiply that volume by your concentration to confirm you are getting 7.5 mg

Rapid-acting or regular insulin is used to cover bolus insulin needs

Choose Semaglutide (Wegovy) If: Best for people who: Want the longest safety track record (5 years) Have good insurance coverage for Wegovy specifically Prefer lowest discontinuation rate (6.9%) Are satisfied with 15% average weight loss Advantages: Most real-world data, proven track record since 2021 Disadvantages: Lowest efficacy (14.9%), highest cost ($1,349/month) Choose Tirzepatide (Zepbound) If: Best for people who: Want highest efficacy among available options (22.5%) Prefer best tolerability (31% nausea, lowest) Want better value (~$290/month cheaper) Want medication available today Advantages: Superior efficacy, best side effect profile, lower cost Disadvantages: Less long-term data than Semaglutide (3 years vs 5) Consider Waiting for Retatrutide If: Might make sense if you: Can wait until 2027-2028 without health consequences Want maximum weight loss (28.7%) Have tried both Semaglutide and Tirzepatide with insufficient results Have flexible health timeline Advantages: Highest efficacy (28.7%) Disadvantages: a year or more of waiting (realistically until second half of 2027 at the earliest), highest discontinuation (18.2%), no long-term data Realistic Recommendations For most people today: Choose Tirzepatide

JAMA Netw Open 2024;7:e2350408.ArticlePubMedPMC 63

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