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Tirzepatide Titration After Switching from Semaglutide Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Weeks 17-20: 12.5mg once weekly Week 21+: 15mg once weekly (maintenance) Step 4: Expect GI Side Effects to Resurface Temporarily Nausea, constipation, and diarrhea are the most common side effects during the switch, consistent with starting any GLP-1 treatment