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The loss of GLP-1 effect on stimulating insulin secretion at basal plasma glucose concentrations limits the hypoglycemic risk even at high pharmacological concentrations of GLP-1 (58)
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Most side effects are not dangerous and are usually digestive
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It is normal not to lose much (or any) weight during the first week of semaglutide GLP-1 treatment
Metformin has been found to produce antidepressive effects by enhancing the responsiveness of the serotoninergic neurons in the dorsal raphe [47], but the main impact of GLP-1 is exerted by AMP-activated protein kinase (AMPK), a major cellular regulator of lipid and glucose metabolism [48]
