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When estrogen levels drop at menopause, your natural GLP-1 production decreases
In clinical trials like SURMOUNT-1, approximately 6% to 7% of patients reported constipation, but in real-world clinical practice, we see this number much higher
Collectively, these observations support the view that inter-individual variability in GLP-1 RA efficacy may, at least in part, reflect differences in baseline gut barrier integrity and microbiome functional capacity, which may distinguish responders from non-responders
Lifestyle modifications are often recommended in managing acid reflux, such as avoiding specific foods and eating smaller, more frequent meals
Side Effects & Safety Per REDEFINE 1 and the Lau (2021) phase 2 program, trial-reported adverse events include: Nausea -- most common (25-40%)
Starting with a low semaglutide dose of 0.25 mg allows the body to adjust gradually, minimizing the risk of adverse effects, particularly gastrointestinal symptoms common at the beginning of treatment
