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In September 2023, the FDA classified BPC-157 as a Category 2 compound under the 503A bulking list, restricting its use by American compounding pharmacies

Store it in the main body of the refrigerator, not in the door where the temperature fluctuates

used natural polyphenol resveratrol to assemble with NR into microspheres, with remarkably elevated NR bioavailability in various organs, such as heart, brain and kidney, and alleviated ischemia-reperfusion injury in mouse heart is observed

The compounds require injection, and access can be limited due to cost and shortages

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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months