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Systemic administration produced equally impressive results: in cardiac ischemia models, doses ranging from 400 ng to 15 mg per animal reduced infarct size, improved myocardial function, and enhanced survival through activation of integrin-linked kinase and Akt pathways promoting cardiac cell migration and angiogenesis while preventing excessive fibrosis

Cuadrado et al., 2020) and pharmacological activation of Nrf2 might also limit NF-B-mediated pulmonary inflammation caused by SARS-CoV-2 infection (Cuadrado et al., 2019, 2020

Several studies have shown that metformin also lowers cholesterol levels, TG, LDL-cholesterol and HDL-cholesterol

[ Links ] Pande S, Brion LP, Campbell DE, Gayle Y, Esteban-Cruciani NV

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The expert gave nuanced additions and clarification to questions or statements