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79 However, the FDA revised its guidance in 2020, moving toward a risk-based approach in which the need for a cardiovascular outcome trial is determined based on the drugs characteristics, safety profile, and existing cardiovascular risk data

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These findings underscore the potential of glycitin as an anticonvulsant agent, elucidating its mechanism of action through histological protection, modulation of oxidative stress markers, and activation of the Nrf2/HO-1 signaling pathway

Glycyrrhizin-mediated liver-targeted sodium alginate nanogels may represent a promising approach for the treatment of acute liver failure (Zhao et al., 2021)

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Clin J Pain 2008;24(8):731-733