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Functionally, GIP receptor activation improves intracellular Ca 2+ concentration, glucagon secretion, and cell depolarization by increasing cAMP/PKA signaling pathways [75, 76]

Treatment with TMZ, PB, or their combination substantially attenuated this loss, producing positive percent changes of +18.86% 6.73%, +17.11% 5.75%, and +19.14% 6.39%, respectively

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