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Managing hydration on GLP-1 treatments Preventative strategies Increase fluid intake to at least 2-3 litres daily (unless contraindicated) Monitor urine colour aim for pale yellow as an indicator of good hydration Establish a regular drinking schedule rather than relying on thirst Use oral rehydration solutions if experiencing significant fluid losses Track daily fluid intake using a dedicated water bottle or app Dietary considerations Consume hydrating foods (fruits, vegetables, soups, broths) Replace electrolytes lost through vomiting or diarrhoea Limit caffeine and alcohol which can worsen dehydration Consider small, frequent sips if nausea makes drinking difficult Include foods with high water content like cucumber, watermelon, and celery Monitoring approaches Weigh yourself regularly rapid weight loss may indicate fluid loss Check for skin turgor by pinching skin on the back of hand

Post-mortem analysis of human brains from AD patients showed that that A 40 discriminated between AD patients and high pathology controls more readily than A 42 (Gao et al., 2010)

Dominant negative mutation in oxalate transporter SLC26A6 associated with enteric hyperoxaluria and nephrolithiasis

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One of those assigned to work on GLP-1 at Novo Nordisk was Lotte Bjerre Knudsen (figure 37), a young researcher hired by the company in 1989 straight after she completed her chemistry training at the Technical University of Denmark

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