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Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues

Hadzic et al., 2005

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Both GHK-Cu and NAD+ are generally safe for all skin types when properly administered

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Typically administered weekly, they can be given intramuscularly or subcutaneously