Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]
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Common side effects include shakiness, headache, and increased heart rate, which often diminish with continued use
This analysis revealed that there was not a significant or consistent relationship between treatment duration and post cessation weight regain
There was a small improvement in BUN/creatinine ratio by the end of the study, but the improvement was not statistically significant
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