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Its interactions with the vagus nerve have been investigated in the context of brain-gut axis effects, including gastroparesis (delayed gastric emptying), where BPC-157 has shown consistent pro-motility effects in preclinical models through vagal cholinergic pathways

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( Pharmaceuticals , 2026) reviewed BPC-157 in Achilles tendon repair and muscle-to-bone healing, with proposed mechanisms involving EGR-1 gene upregulationa transcription factor important in tendon and ligament repair

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