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Preparation of samples and transmission electron microscopy imaging were done as previously described [24]

Ethical approval The study was submitted to the Ethics Committee of 12 de Octubre Hospital (Madrid, Spain), which judged that, due to the nature of the study, further approval was not required

Soria-Castro, E

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Pyruvate kinase M2 regulates Hif-1 activity and IL-1 induction and is a critical determinant of the warburg effect in LPS-activated macrophages