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There are some data that acute COVID-19 infection is accompanied by signs of oxidative stress, including increased expression of ROS-response genes and glycolysis in peripheral blood mononuclear cells [72], increased MDA (TBARS assay), F-isoprostane, 8-hydroxy-2-deoxyguanosine, AOPP and nitrotyrosine levels, and lowered glutathione (GSH), -SH groups, selenium, zinc, TAC and vitamin D [49, 73,74,75,76,77,78,79]

2 Specifically, the FDA has made clear in guidance that it does not intend to take action against state-licensed pharmacies or licensed physicians that compound from a Category 1 bulk, provided that: (i) the bulk is manufactured solely in FDA-registered establishments

In addition, transcription factorsincluding Fos , Junb and Egr1 were also upregulated, which is consistent with our transcriptomic analysis of Caco-2 cells treated with clofazimine (Extended Data Fig

6 , eaaz8534 (2020)