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Semaglutide is a GLP-1 receptor agonist licensed in the UK exclusively for type 2 diabetes mellitus treatment Weight loss from Ozempic can disrupt the hypothalamic-pituitary-ovarian axis, affecting oestrogen levels and menstrual regularity Women with PCOS may experience restored ovulatory cycles due to weight reduction, whilst others may develop temporary amenorrhoea Menstrual cycle changes are not listed as direct adverse effects in the MHRA-approved Summary of Product Characteristics Women should contact their GP for heavy bleeding, postcoital bleeding, amenorrhoea exceeding three months, or severe pelvic pain Effective contraception is essential as fertility may unexpectedly return with weight loss and metabolic improvement Table of Contents Does Ozempic Affect Your Menstrual Cycle