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In mice, TLC-2716 was administered orally at 15, 60 and 120 mg per kg (body weight) per day (7- to 57-fold the maximum clinical dose) to lean male and female CD-1 mice for 26 weeks
Neural tissue cannot tolerate prolonged oxidative stress the way slower-metabolizing tissues can
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In PD, GSH impacts the degeneration of dopaminergic neurons
N-acetyl cysteine is no longer available on Amazon (which may not be the best source of supplements anyway) but NAC is still available from Prohealth, Thorne, Jarrow, Life Extension and other vitamin companies
This is more of a strategy than a therapy but it relies on integrating biomarker knowledge (like measuring mtDNA kinetics, mitochondrial respiration in blood cells ex vivo , etc
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