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Biochemistry 57 , 20592060 (2018)

FDA-Noted Concerns: Increased heart rate Systemic vasodilatory reactions Limited clinical safety data Immunogenicity risk (antibody formation) Reported Side Effects: Injection site reactions (redness, swelling, itching) Headache Flushing Dizziness Nausea Water retention Serious Concerns: Potential for glucose metabolism disruption Theoretical cancer risk (GH/IGF-1 promote cell proliferation) Long-term safety unknown Regulatory Status United States: CJC-1295 is not FDA approved for any indication

The antimicrobial efficacy of these compounds ranged from strong to moderate

Bullous pemphigoid associated with dipeptidyl peptidase-4 inhibitors: a report of five cases

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